Allergies & Asthma

It remains “unclear” whether the modest effects of gefapixant, an investigational drug for chronic cough, represent a clinically meaningful benefit, said FDA staff ahead of a meeting of the agency’s Pulmonary-Allergy Drugs Advisory Committee. On Friday, committee members will wrestle with exactly what constitutes a meaningful benefit for this incredibly common condition, as no threshold
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[embedded content] Internal medicine and rheumatology specialist Siobhan Deshauer, MD, takes us through a medical case study: cardiac arrest after red meat consumption. Following is a transcript of the video (note that errors are possible): Deshauer: Hey, guys. I’m Siobhan, an internal medicine and rheumatology specialist. Today, I’m going to tell you about Tom, a
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This is the first in an occasional series on the origin of commonly used medicines. When epinephrine was first discovered at the turn of the 20th century, it was essentially a drug without a disease. In 1894, two British researchers — physician George Oliver and physiologist Edward Albert Sharpey-Schafer — discovered that the extract of
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Hailed for opening a new chapter in food allergy management, oral immunotherapy (OIT) is nevertheless going through growing pains in accessibility and acceptance in clinical practice. In 2020, the FDA approved peanut allergen powder (Palforzia), an OIT developed to combat allergic reactions to peanuts — a departure from traditional allergen avoidance and anaphylaxis treatment. The
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The FDA declined to approve oral gefapixant for treating chronic cough, Merck announced on Wednesday. In its complete response letter, “the FDA concluded that Merck’s application did not meet substantial evidence of effectiveness” for the treatment of unexplained or refractory chronic cough, according to the drugmaker, but no safety concerns were cited. No approved drug
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This time of year, people are going house-to-house for gatherings of friends, family, and coworkers, and it’s always thoughtful to bring the host a small gift. There are so many options out there, but some may not be ideal for those with allergies or asthma. Here are a few things to avoid and alternative ideas
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You’re never too old to try new things — and that includes allergy treatment. It’s a common misconception that only children and young adults can benefit from treatment, when there is truly no “bad” or “wrong” time to retrain your body to not react to problematic allergens. Read on to learn about adult-onset allergies and
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Oral Immunotherapy, or OIT, and Sublingual Immunotherapy (SLIT), are often talked about as treatments for food allergy. Each treatment has benefits, but they are different approaches. Let’s talk about how they differ, and how that can impact which approach to choose. The only way to treat the cause of allergies is through immunotherapy, where tiny
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HONOLULU — Sexual and gender minoritized (SGM) adults are at an increased risk for severe asthma, according to an analysis of a nationally representative study. Compared with straight people, asthma attacks that required the use of steroids were more likely among SGM patients (OR 1.47, 95% CI 1.01-2.15), reported Tugba Kaplan, MD, of Luminis Health-Anne
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A minority of families and healthcare providers were willing to have pediatric emergency departments (EDs) conduct a direct oral challenge (DOC) to delabel penicillin allergies in children, a cohort study showed. After considering the child’s risk category, family interest, and clinician willingness, 117 parents had their low-risk child complete the DOC out of the 1,189
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HONOLULU — Exposure to colder temperatures, especially those below 20°F, was associated with an increased risk for chronic obstructive pulmonary disease (COPD) exacerbations leading to hospitalizations in older adults, an analysis of 2007-2019 Medicare data showed. From November to February, there was a 1.5- to 2-fold increase in hospitalizations for Medicare beneficiaries with COPD, reported
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